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What Dithrocream is and what it is used for.Dithrocream is a treatment for careful application to localised areas of your skin and scalp affected by a particular type of psoriasis that doctors refer to as sub-acute or chronic psoriasis.This type of psoriasis involves areas of raised, red patches of skin, covered with silvery scales (without any blistering or tenderness). The patches often occur on the elbows, knees, lower back and scalp.Dithrocream is recommended for use by adults, the elderly and children.The active ingredient in this product is dithranol. It helps to clear patches of psoriasis by restoringnormal skin development.Dithrocream is available in five strengths that have colour coded packs, as follows: 0.1% - in a pale blue pack 0.25% - in a red pack 0.5% - in a purple pack 1.0% - in a brown pack
Do not use this product: on psoriasis that feels and looks sore and angry, or on pustular psoriasis (which is very tender, inflamed, and involves small blisters filled with pus); to treat areas of psoriasis on your face; if you are allergic (hypersensitive) to dithranol or any of the other ingredients. Take special care when using this product: Dithranol can cause skin burning and excessive soreness if not used correctly. It is therefore veryimportant that you: use the correct strength of Dithrocream for your particular requirements; apply it carefully, only to the patches of psoriasis, and; limit the contact time on your skin; only use the three highest strengths, Dithrocream 0.5% w/w and 1.0% w/w, if recommended by a doctor and if you have failed to respond to the lower strengths; avoid using this product (unless advised by your doctor) to treat psoriasis on areas of folded skin,such as the groin or underneath the breasts. This is because the skin’s response to Dithrocream tends to be stronger in these areas. If you have been given a high strength of Dithrocream (0.5% w/w or 1.0% w/w) to use on areas of folded skin, return to your doctor for further advice; keep the cream away from your eyes, nose and mouth; always wash your hands thoroughly after use. Dithranol causes staining: avoid contact with fabrics, plastics and other materials, such as bedclothes, furnishings and bathand shower fittings, because this is likely to cause permanent staining which cannot be removed; treated areas of skin may gradually become stained purple or brown. This is harmless, and will gradually disappear within a few days after the end of your treatment; blonde or fair hair may take on a pinkish tinge when treating the scalp. This will grow out after treatment stops. For children, use with extra caution and with regular supervision. Using other medicines If you have been regularly using topical corticosteroids to treat your psoriasis it is important that you allow yourself a treatment-free interval of at least one week before starting to use Dithrocream. You can use a plain emollient (skin moisturiser) on your skin in the meantime. Pregnancy and breast-feeding Dithrocream can be used during pregnancy and whilst breast-feeding. The ingredients have been inwidespread use in this and similar preparations for many years, without reports of problems. However, safety trials have not been conducted. Driving and using machinery Using this product is not known to affect your ability to drive or use machinery. Important information about two of the ingredients of Dithrocream This cream contains a small amount of cetostearyl alcohol. This ingredient may cause local skin reactions (e.g. contact dermatitis) in a small number of people who are sensitive to it. The cream also contains chlorocresol. This ingredient may cause allergic reactions in rare cases. If you have been told by your doctor that you are sensitive to cetostearyl alcohol or chlorocresol, please talk to your doctor before using this product. If the cream gets into your eyes, nose or mouth, it may be strongly irritant. If this happens, rinse the affected areas with plenty of water. If rinsing one eye, take care to avoid washing product into the other eye. If irritation persists, tell your doctor or pharmacist. If the cream accidentally gets onto normal skin, wipe it off straight away with a tissue, and wash the area with soap and warm water. If the cream is accidentally swallowed, go to a hospital Accident & Emergency department straight away because it is a strong laxative and you may need a stomach washout. If you use too high a strength or leave it in contact with your skin for too long, it may cause skin burning and excessive soreness, in which case the dosage should be reviewed by your doctor. If you occasionally forget to use this product, do not worry. Just carry on using it when you remember. If you have any further questions on the use of this product, ask your doctor or pharmacist. Possible side effects While Dithrocream is working, some skin redness and a feeling of mild ‘sunburn’ at the site of application is quite normal, indicating that it is working. If excessive burning or soreness occurs, this usually means that the strength being used is too high or that the cream is being left in contact with the skin for too long. If this happens, treatment should be stopped at once and the dosage reviewed by your doctor. Your doctor may advise you to use a lower strength, to apply it for shorter contact periods or to apply it less often. Like all medicines, Dithrocream can cause other side effects, although not everybody gets them: If you mistakenly allow the cream to spread onto, and remain in contact with, areas of normal skin, it is more likely to cause burning and soreness. Temporary staining of the skin or hair can occur. However, this will gradually go away after treatment has stopped. On very rare occasions allergic reactions to the ingredients can occur. These may result in local skin inflammation, itching and redness, in which case treatment with Dithrocream should be stopped. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. Any staining caused by getting the cream on your clothes, bed linen, fabrics, plastics or other materials is likely to be permanent. How to store dithrocream Keep it out of the reach and sight of children. Always replace the cap tightly after use. Do not store the product above 25°C. Do not use after the expiry date shown on the fold of the tube and the carton. The expiry date refers to the last day of that month. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
Use Dithrocream only on patches of skin affected by the particular type of psoriasis that it is recommended for. Before using this tube for the first time, open it as follows: Unscrew the cap, turn it upside down and then use the sharp point of the cap to pierce the membrane in the neck of the tube. To use the cream (for adults, the elderly and children): Follow instructions a) to d) below carefully otherwise the cream may cause skin burning and excessive soreness: a) Make sure that you start treatment with the correct strength of Dithrocream: If you have not used Dithrocream before, or if you are about to use it on patches of psoriasis on areas of your body where you have not used it previously, always start treatment with the lowest strength of Dithrocream, 0.1% w/w. Use this strength for at least a week and then, only if recommended by your doctor or pharmacist, increase at weekly intervals to the 0.25% w/w, followed by the 0.5% w/w, the 1.0% w/w. The aim is to start with the lowest strength and build up gradually over approximately 4 weeks to the highest, optimum strength that does not cause excessive sensation of skin warmth. This optimum strength differs for each of us, and may also depend upon the thickness and location of your psoriatic patches. Your doctor should help you decide which strength is best for your particular circumstances. b) Make sure that you always apply Dithrocream carefully as follows: Apply it thinly and only to the patches of psoriasis. Rub the cream gently into the psoriasis patches until completely absorbed, otherwise any excess cream may spread onto normal skin areas (where the skin reaction is much stronger), or spread onto clothing or bedding, causing staining. Always wash your hands immediately after use. c) Make sure that you apply the cream only once a day, and always limit the ‘contact’ time withyour skin, using one of the following methods to stop it working for too long: either use ‘short contact treatment’ lasting up to one hour, in which case: apply the cream at any convenient time of the day or evening, then; usually no more than one hour later, bathe or shower to wash the cream off. or use ‘overnight treatment’, in which case: apply the cream at night before going to bed, then; the following morning, bathe or shower to wash the cream off. Because using it ‘overnight’ involves a longer contact time, this option is only advised when using the lower strengths of Dithrocream. d) For use on scalp psoriasis: First comb the hair to remove any loose scales, then, after suitably parting the hair, massage thecream well into the affected areas. Use it only once a day, and stop the cream working after the required contact time on the scalp byshampooing the hair as normal. Take great care when washing out the shampoo (which may contain some Dithrocream residue)to avoid getting it into the eyes or on the face. This is particularly important when using the higher strengths of Dithrocream. To avoid unnecessary staining to clothing and bed linen etc, you could wear an old pair of pyjamas and / or dressing gown and, when treating the scalp, use an old pillowcase. Carry on using Dithrocream for long enough: Continue this daily treatment, using the highest strength of Dithrocream that does not causeexcessive sensation of skin warmth, until your skin is completely better, ie when there is nothing tofeel with the fingers and the skin texture is normal. By gradually increasing the strength of Dithrocream applied, it should be possible to clear psoriasispatches within 4 to 6 weeks. Look after your bath or shower to prevent the possibility of staining, particularly where Dithrocream1.0% has been used. Always rinse the bath or shower with hot water immediately after washing or showering, and then use a suitable detergent to remove any deposit from the surface of the bath or shower. Wear protective gloves to avoid irritating your hands.
The active ingredient in the Dithrocream range is dithranol, at five different strengths comprising 0.1% w/w, 0.25% w/w, 0.5% w/w and 1.0% w/w. The other ingredients are white soft paraffin, cetostearyl alcohol, salicylic acid, ascorbic acid, sodium laurilsulfate, chlorocresol and purified water.